COMPARISON OF DIAZEPAM WITH MIDAZOLAM AS I.V. SEDATION FOR OUTPATIENT GASTROSCOPY

Propofol sedation for outpatient upper gastrointestinal endoscopy: comparison with midazolam.

The objectives of this study were to assess midazolam and propofol as sedative agents for outpatient gastrointestinal endoscopy, with particular reference to recovery profile, amnesic effects, and haemodynamic state and oxygenation during the procedure. Forty consecutive patients were allocated randomly to two groups. Patients in group I (n = 19) received midazolam 81 (SEM 32) micrograms kg-1; ...

Diazepam and midazolam for sedation during bronchoscopy.

Sir,—It is regretted that the interesting paper by Korttila and Tarkkanen (1985) does not state which preparation of diazepam they used. The early relative potency studies of midazolam and diazepam were undertaken with the organic solvent preparation, Valium. A review (Dundee et al., 1984) of these puts the relative potency of the two drugs at about 1.5:2.1:1. However, if Korttila and Tarkkanen...

Comparison of the i.v. administration of midazolam and diazepam as sedation during spinal anaesthesia.

Midazolam hydrochloride and diazepam in emulsion were compared as i.v. sedatives for spinal anaesthesia. Mean doses of midazolam 12 mg and diazepam 27 mg were required to induce sleep and provide good or adequate sedation throughout surgery of approximately 1 h duration. Neither drug caused loss of the airway or significant cardiorespiratory changes. The frequency of drowsiness after operation ...

Comparison of diazepam and midazolam for sedation during local anaesthesia for bronchoscopy.

Bronchoscopy was performed in 76 outpatients using local anaesthesia plus diazepam 0.2 mg kg-1 i.v. or midazolam 0.05 or 0.1 mg kg-1 i.v. Patient co-operation and ease of bronchoscopy were good in all patients. Two hours after injection, 67% (diazepam 0.2 mg kg-1), 36% (midazolam 0.05 mg kg-1) and 75% (midazolam 0.1 mg kg-1) of the patients failed to recall the insertion of the bronchoscope. Si...

Intravenous sedation for upper gastrointestinal endoscopy: diazepam versus midazolam.